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This study was undertaken to determine the effect of dichloroacetate (DCA) on myocardial functional and metabolic recovery following global ischemia. Isolated rabbit hearts were subjected to 120 min of mildly hypothermic (34°C), cardioplegic arrest with multidose, modified St. Thomas’ cardioplegia. Hearts were reperfused with either physiologic salt solution (PSS) as controls, (CON,n= 10) or PSS containing...