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Mouse αA-crystallin gene encodes the most abundant protein of the mammalian lens. Expression of αA-crystallin is regulated temporally and spatially during lens development with initial expression in the lens vesicle followed by strong upregulation in the differentiating primary lens fibers. Lens-specific expression of αA-crystallin is mediated by DNA-binding transcription factors Pax6, c-Maf and CREB...