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BackgroundThe significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood.
MethodsWe performed a retrospective review of patients with advanced‐stage (stage III or stage IV) cutaneous SCC of the head and neck (n = 56).
ResultsThe majority of patients (91%) had stage III disease, with 54% having...
The HNSCC cell line, FaDu was stably transfected with control vector (FaDu) or with plasmid expressing small interfering RNA against EMMPRIN (FaDu/siE). Tumor cells were treated with bevacizumab (0, 25, 50, and 75ng/ml) in vitro, and then cell counts were performed at 72h. For in vivo analysis, tumor cells were xenografted onto the flank of SCID mice, and were treated with 100μg bevacizumab twice...
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