Search results for: Hannelore Schmidt

Items from 1 to 17 out of 17 results

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Primitive Neuroectodermal Tumor (PNET) of the Urinary Bladder

Stefan Krüger, Hannelore Schmidt, Ingo Kausch, Andreas Böhle, more

Pathology - Research and Practice > 2003 > 199 > 11 > 751-754

We report on the clinical, morphologic, immunohistochemical, ultrastructural, and molecular cytogenetic features of a primitive neuroectodermal tumor (PNET) primarily arising in the urinary bladder. An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the...

article

Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma

Peter Würl, Matthias Kappler, Axel Meye, Frank Bartel, more

The Lancet > 2002 > 359 > 9310 > 943-945

Increased expression of survivin has been shown to be a negative predictor of survival in patients with soft-tissue sarcoma. We investigated 89 adults with soft-tissue sarcomas to ascertain the relation between co-expression of survivin and human telomerase reverse transcriptase (TERT) transcripts and prognosis. We quantified mRNA expression of survivin and TERT transcripts. Cox's proportional-hazards...

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Fibrosarcoma Associated with a Benign Cystic Teratoma of the Ovary

Stefan Krüger, Hannelore Schmidt, Wolfgang Küpker, Friedrich W. Rath, more

Gynecologic Oncology > 2002 > 84 > 1 > 150-154

Objective. A case of ovarian fibroscarcoma associated with a benign cystic teratoma is described.Methods. A 32-year-old patient with an ovarian tumor detected by routine gynecological examination was referred to our hospital. In addition to histopathological examination of the resected tumor, immunohistochemical studies as well as a cytogenetic analysis by comparative genomic hybridization were carried...

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Low detection rate of p53 antibodies in sera of soft tissue sarcoma patients

Peter Würl, Marina Fittkau, Axel Meye, Frank Bartel, more

Cancer Letters > 2001 > 170 > 2 > 199-205

Accumulation of the p53 gene product can lead to its immunogenic appearance and the generation of p53 serum antibodies (p53ab). In different cancer types the occurrence of detectable p53ab has an independent prognostic impact. In spite of the known p53 protein overexpression rate in soft tissue sarcomas (STS), up to 70%, there have been no investigations done on p53ab in serum in STS patients. In...

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Cytogenetic characterization of six malignant peripheral nerve sheath tumors - comparison of karyotyping and comparative genomic hybridization

Hannelore Schmidt, Helge Taubert, Peter Würl, Matthias Bache, more

Cancer Genetics and Cytogenetics > 2001 > 128 > 1 > 14-23

We analysed six malignant peripheral nerve sheath tumors (MPNSTs) from four patients using metaphase preparations and compared the results with those obtained by using comparative genomic hybridization (CGH). All six tumors showed structural and numerical chromosomal aberrations, mostly of chromosomes 1, 5, 7-10, 14-17, 19, 21, and 22. The number of chromosomes per tumor cell ranged from 42 to 104...

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A MboII polymorphism in exon 11 of the human MDM2 gene occuring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?

Helge Taubert, Matthias Kappler, Axel Meye, Frank Bartel, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2000 > 456 > 1-2 > 39-44

The human MDM2 oncogene, well known as the tumor suppressor gene p53's partner, plays an important role in tumorigenesis whether it is dependent on or independent of TP53. In this study, we investigated in a PCR-sequencing analysis the exon 11 of the human MDM2 gene for gene alterations. A MboII polymorphism occurs in 8% of normal blood donors (8 out of 100 probands) and in 13% of the soft tissue...

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Gains in chromosomes 7, 8q, 15q and 17q are characteristic changes in malignant but not in benign peripheral nerve sheath tumors from patients with Recklinghausen's disease

Hannelore Schmidt, Helge Taubert, Axel Meye, Peter Würl, more

Cancer Letters > 2000 > 155 > 2 > 181-190

In order to investigate typical genomic alterations in patients with Recklinghausen's disease (NF1) we studied one from each of the six patients with NF1 several benign and/or malignant tumors. By means of comparative genomic hybridization (CGH) gained results from six benign neurofibromas and 14 malignant peripheral nerve sheath tumors (MPNSTs) were compared with four benign peripheral nerve sheath...

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Colony formation of soft tissue sarcoma cells is inhibited by lipid-mediated antisense oligodeoxynucleotides targeting the human mdm2 oncogene

Axel Meye, Peter Würl, Matthias Bache, Frank Bartel, more

Cancer Letters > 2000 > 149 > 1-2 > 181-188

More than one third of human soft tissue sarcoma (STS) have elevated levels of the MDM2 oncoprotein, resulting either from gene amplification or alternate mechanisms. MDM2 functions as a negative feedback regulator of the tumor suppressor p53. The aim of the present study was to investigate whether mdm2-antisense oligodeoxyribonucleotides (AS-ODNs) can influence the growth characteristics of two MDM2-overexpressing...

article

mdm2 mRNA Level is a Prognostic Factor in Soft Tissue Sarcoma

Helge Taubert, Thomas Koehler, Axel Meye, Frank Bartel, more

Molecular Medicine > 2000 > 6 > 1 > 50-59

Background The oncogenic properties of murine double minute-2 (mdm2) protein over-expression, which mostly results from the interaction with the tumor suppressor p53, are well described and their negative impacts on the prognosis of affected patients is well characterized. However, clinical relevance of mdm2 mRNA expression is poorly investigated. Materials and Methods In this study, 65 soft tissue...

article

Clinical relevance of pRb and p53 Co-overexpression in soft tissue sarcomas

Peter Würl, Axel Meye, Christine Lautenschläger, Hannelore Schmidt, more

Cancer Letters > 1999 > 139 > 2 > 159-165

The goal of this study was to examine the relationship between immunohistochemical pRb detectability and p53 overexpression in 198 soft tissue sarcomas (STS) with regard to its clinical relevance. Distinct pRb detectability multivariately shows a correlation to survival rate (relative risk (RR) = 1.59, P=0.037). p53 positivity was also multivariately correlated to poor prognosis (RR=2.17, P=0.0014)...

article

Backbone Stabilized Peptidomimetics Containing Statine-Like Structural Elements: Diastereospecific Synthesis of Trisubstituted Cyclic Ureas and 1,4-Diazepan-2-ones

Dieter Scholz, Peter Hecht, Hannelore Schmidt, Andreas Billich

Monatshefte für Chemie - Chemical Monthly > 1999 > 130 > 10 > 1283-1300

Summary. 2-Aminobenzyl substituted 4-amino-3-hydroxy-5-phenyl pentanoic acid (AHPPA) is the central structural element of highly active HIV-protease inhibitors. To obtain conformationally less flexible statine analogs, we stabilized AHPPA via ring formations, e.g. by reaction with 1,1′-carbonyl diimidazole to give six-membered ureas. Reaction of AHPPA with chloroacetyl chloride leads to 1,4-diazepan-2-ones,...

article

Backbone Stabilized Peptidomimetics Containing Statine-Like Structural Elements: Diastereospecific Synthesis of Trisubstituted Cyclic Ureas and 1,4-Diazepan-2-ones

Dieter Scholz, Peter Hecht, Hannelore Schmidt, Andreas Billich

Monatshefte für Chemie - Chemical Monthly > 1999 > 130 > 10 > 1283-1300

Summary.2-Aminobenzyl substituted 4-amino-3-hydroxy-5-phenyl pentanoic acid (AHPPA) is the central structural element of highly active HIV-protease inhibitors. To obtain conformationally less flexible statine analogs, we stabilized AHPPA via ring formations, e.g. by reaction with 1,1-carbonyl diimidazole to give six-membered ureas. Reaction of AHPPA with chloroacetyl chloride leads to 1,4-diazepan-2-ones,...

article

Cytogenetic Characterization of Ten Malignant Fibrous Histiocytomas

Hannelore Schmidt, Sabine Körber, Raoul Hinze, Helge Taubert, more

Cancer Genetics and Cytogenetics > 1998 > 100 > 2 > 134-142

We examined 10 malignant fibrous histiocytomas (MFHs) using metaphase preparations. Six tumors showed clonal structural and/or numerical chromosomal aberrations, and four tumors had normal karyotypes. For the most part, chromosomes 1, 3, 6, 9, 12, 16, 18, and 20 were involved in structural aberrations. The breakpoint regions most frequently were in 1p32, 3p25, and the centromeric region of chromosomes...

article

p53 status in radiation-induced soft-tissue sarcomas

Helge Taubert, Axel Meye, Matthias Bache, Raoul Hinze, more

Strahlentherapie und Onkologie > 1998 > 174 > 8 > 427-430

Background Following therapeutic irradiation after a latency period of many years radiation-induced tumors, often sarcomas, can arise. Results of radiation-induced DNA damage can be 1. p53 over-expression, inducing growth arrest or apoptosis, and 2. occurrence of mutations, frequently including the p53 gene, as one molecular promotor for carcinogenesis. We were interested whether radiation-induced...

article

Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma

Peter Wrl, Axel Meye, Dieter Berger, Christine Lautenschlger, more

Langenbeck's Archives of Surgery > 1998 > 383 > 1 > 99-103

Abstract The growth regulatory function of the retinoblastoma protein (RB) can be suppressed by mdm2 via RB/mdm2 interaction by perturbation of the RB suppression of the E2F function. The goal of this study was to examine the clinical value of immunohistochemical (IHC) RB detection and its relationship to mdm2 overexpression in a cohort of 198 adult primary soft-tissue sarcomas (STS). RB overexpression...

article

A novel type of adhering junction in an epithelioid tumorigenic rat cell culture line

M. Schmelz, Dennis L. Way, Peter Borgs, Wiebke K. Peitsch, more

Cell and Tissue Research > 1998 > 294 > 1 > 11-25

AbstractTwo major types of plaque-bearing adhering junctions are commonly distinguished: the actin microfilament-anchoring adhaerens junctions (AJs) and the desmosomes anchoring intermediate-sized filaments (IFs). Both types of junction usually possess the common plaque protein, plakoglobin, whereas the other plaque proteins and the transmembrane cadherins are mutually exclusive. For example, AJs...

article

Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: a multivariate analysis of five antibodies

Peter Wrl, Helge Taubert, Axel Meye, Dieter Berger, more

Journal of Cancer Research and Clinical Oncology > 1997 > 123 > 9 > 502-508

Abstract Most changes of tumor suppressor p53 and its pathway involve a protein with prolonged half-life that permits immunohistochemical detection. The goal of this study was to compare the prognostic relevance of five different p53 antibodies in primary soft-tissue sarcomas (STS) with known p53 mutation status, using a multivariate Cox regression model (adjusted to tumor grading, staging, localization,...

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