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The nanoassemblies were prepared from N-octadecanoyl gemcitabine (NOG)/cholesteryl succinyl poly(ethylene glycol) 1500 (CHS-PEG 1500 ) (5:1, mol/mol). They showed higher cytotoxicity than gemcitabine on HpG2 cell model. The amphiphilicity of NOG may improve permeation of prodrugs and destruction of cell membrane. The nanoassemblies were rapidly eliminated from circulation after bolus intravenous...
Molecular self-assembly of nucleosides is important, and the resulting nanostructures may be used in drug delivery. Gemcitabine, a nucleoside anticancer agent, was conjugated with long-chained fatty acids to obtain two amphiphilic derivatives, N-octadecanoyl gemcitabine (NOG) and N-dodecanoyl gemcitabine (NDG). NDG formed a more flexible monolayer at the air/water interface than NOG. The mixed monolayers...
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