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Metformin (1,1-dimethylbiguanide; MET) is used in the treatment of type 2 diabetes mellitus. MET's antihyperglycemic action depends at least in part on its inhibitory effect on hepatic gluconeogenesis. As to gluconeogenesis from amino acids (e.g. l-alanine), this is associated with an inhibition of l-alanine uptake into hepatocytes. Since this uptake is mediated by an electrogenic transport mechanism,...