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In hospitalized patients, the optimal target blood glucose concentration is controversial. Numerous studies have examined clinical use of glucose control in various patient populations. In the present review, we briefly discuss corresponding meta-analyses. We electronically searched MEDLINE, EMBASE and CINAHL for meta-analyses relevant to the subject. Fifteen meta-analyses were identified that analyzed...
The Nutritional Risk Screening-2002 (NRS-2000) is currently recommended by the European Society of Parenteral and Enteral Nutrition as a screening tool in hospitalized patients. However, for preoperative risk prediction, the usefulness of this tool is uncertain and may depend on the type of surgical disease. The present study investigated the relative prognostic importance of the NRS-2002 and of established...
Duration of surgical therapy and the number of surgical revisions performed to control the focus may be important prognostic variables. Association of such time-dependent therapies with survival, however, has not yet been studied. We analyzed survival times of adult patients (n = 283) who were suffering from secondary peritonitis and associated organ failure. Cox-type additive hazard regression...
Currently, it is unknown whether recommended rates of amino acid infusion are sufficient to support hepatic or intestinal protein synthesis specifically after operation. The objective of the study was to determine the effect of a standard parenteral amino acid dose on serum albumin and ileum protein synthetic rates in postabsorptive patients recovering from major abdominal operations.Mass spectrometry...
Major abdominal operations were found to be associated with long-lasting metabolic changes, such as accelerated release of stress hormones and carbohydrate turnover. It is unknown currently whether acute changes of hepatic protein metabolism persist in a similar way. We wanted to determine the long-term dynamics of albumin synthesis and its relationship to whole body protein breakdown and albumin...
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