The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Three recent studies, including one in this issue of Molecular Cell, document unexpected physical and functional interactions between two unrelated enzymes: OGT, which transfers O-GlcNAc to serine/threonine residues of numerous cellular proteins, and TET-family dioxygenases, which successively oxidize 5-methylcytosine in DNA.
Summary: Study of the development of distinct CD4+ T‐cell subsets from naive precursors continues to provide excellent opportunities for dissection of mechanisms that control lineage‐specific gene expression or repression. Whereas it had been thought that the induction of transcription networks that control T‐lineage commitment were highly stable, reinforced by epigenetic processes that confer heritability...
Distal cis-regulatory elements play essential roles in the T lineage-specific expression of cytokine genes. We have mapped interactions of three trans-acting factors—NF-κB, STAT4, and T-bet—with cis elements in the Ifng locus. We find that RelA is critical for optimal Ifng expression and is differentially recruited to multiple elements contingent upon T cell receptor (TCR) or interleukin-12 (IL-12)...
Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-β cytokine signaling, which induce divergent fates of Th17 cell precursors. We found that Th17 cell precursors had substantial remodeling of...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.