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Many stem cell populations interact with stromal cells via signaling pathways, and understanding these interactions is key for understanding stem cell biology. In Drosophila, germline stem cell (GSC) maintenance requires regulation of several genes, including dpp, piwi, pumilio, and bam [1–5]. GSCs also maintain continuous contact with cap cells that probably secrete the signaling ligands necessary...
Stem cells execute self-renewing and asymmetric cell divisions in close association with stromal cells that form a niche . The mechanisms that link stromal cell signaling to self-renewal and asymmetry are only beginning to be identified, but Drosophila oogenic germline stem cells (GSCs) have emerged as an important model for studying stem cell niches. A member of the Bone Morphogenetic Protein (BMP)...