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Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody‐mediated immunity. To what extent the same is true for T‐cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4+ T‐cell responses, using adoptive transfer of mouse DO11.10 TCR transgenic T cells specific for OVA and...
Here we demonstrate that by using non-toxic fractions of saponin combined with CTA1-DD we can achieve a safe and above all highly efficacious mucosal adjuvant vector. We optimized the construction, tested the requirements for function and evaluated proof-of-concept in an influenza A virus challenge model. We demonstrated that the CTA1-3M2e-DD/ISCOMS vector provided 100% protection against mortality...
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