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C-terminal fragments from the precursor for gastrin-releasing peptide (GRP) have been detected in several human tumour types. We have previously demonstrated that recombinant human proGRP42–98 is biologically active. To investigate the regions responsible, proGRP42–98 was cleaved with thrombin, and the fragments purified by HPLC. Both proGRP42–79 and proGRP80–98 stimulated proliferation of the human...
Although amidated forms of gastrin-releasing peptide (GRP) have been identified as autocrine growth factors in small cell lung cancer, their role in the development and progression of colorectal carcinoma is less clear. In addition, the biological activity of non-amidated gastrin-releasing peptide has not been investigated in colorectal carcinoma cells. We therefore investigated the effect of bombesin...
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