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Here we investigated the role of cellular phosphatases in activation of homotypic aggregation in leukocytes by adding the phosphatase inhibitors okadaic acid (OA) and calyculin A (CA) to cultures of the human monocytic U937 cell line and the human T-lymphocytic Jurkat cell line. We found that OA produces a 120-fold increase of homotypic aggregation with Jurkat cells and a 200-fold increase with U937...