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This study examines the effects of adrenergic drugs on bicarbonate secretion by the rat caecum in vitro. Noradrenaline, phenylephrine but not clonidine, stimulated secretion in a concentration-related manner. Noradrenaline responses were antagonised by alprenolol (20 μM) but not phentolamine (10 μM) whilst phenylephrine was antagonised by phentolamine (10 μM), prazosin (5 μM) but not yohimbine (5...