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Phospholipase D (PLD) is present in human placental tissue. Since purinergic receptor agonists activate PLD in many different cell types, we evaluated the purinergic activation of the enzyme in cultured trophoblasts from the placenta. We found that P 2 receptor agonists stimulate PLD. The preferred ligand for P 2X7 (P 2Z ) receptor subtype, BzBz-ATP (10 −3 m ), induced...