Search results for: Alfredo Cugola

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article

Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists

Romano Di Fabio, Gianluca Araldi, Davide Baraldi, Alfredo Cugola, more

Il Farmaco > 2001 > 56 > 10 > 791 - 798

After the identification of GV150526, the indole-2-carboxylate template was further explored in order to identify novel potential anti-stroke agents. In particular, the SAR of the side chain present at the C-3 position of the indole nucleus was widely studied. In this paper, the synthesis and the pharmacological profile of a further class of conformationally restricted analogues of GV150526 as in...

article

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as Selective Glycine Antagonist with In Vivo Activity

Fabrizio Micheli, Alfredo Cugola, Daniele Donati, Andrea Missio, more

Bioorganic & Medicinal Chemistry > 1997 > 5 > 12 > 2129-2132

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.

article

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine -N-oxide as selective glycine antagonists.

Alfredo Cugola, Daniele Donati, M. Guarneri, Fabrizio Micheli, more

Bioorganic & Medicinal Chemistry Letters > 1996 > 6 > 22 > 2749-2754

Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor.

INFONA - science communication portal

Search results for: Alfredo Cugola

Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as Selective Glycine Antagonist with In Vivo Activity

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine -N-oxide as selective glycine antagonists.

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INFONA - science communication portal

Search results for: Alfredo Cugola

Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as Selective Glycine Antagonist with In Vivo Activity

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine -N-oxide as selective glycine antagonists.

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