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Menadione, or vitamin K 3 (VK 3 ), a potent oxidative stress inducer, has been recently used as an effective and remarkably safe cytotoxic drug for treatment of several human tumors. VK 3 induces apoptotic cell death through a poorly understood mechanism. Here we show for the first time that VK 3 -induced apoptosis requires the Fas/FasL system. Spleen cells from both...