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The nucleoside hydrolase (NH36) of Leishmania (L.) donovani is a vital enzyme which releases purines or pyrimidines of foreign DNA to be used in the synthesis of parasite DNA. As a bivalent DNA vaccine, the VR1012-NH36 was immunoprotective against visceral and cutaneous murine leishmaniasis. In this work we tested the immunotherapy against Leishmania (L.) chagasi infection, using two doses of 100...
The presence of aldehyde groups at C-23 and C-24 of the triterpen aglycon moiety was disclosed in 1 H NMR spectra of both the Riedel de Haen saponin (R) (δ 9.336) and Quillaja saponaria QuilA saponin (δ 9.348). The sign of the C-28 acylated linked moiety (δ 176) was present in both saponins, while the δ 171 at C-28 (carboxy group) corresponding to the deacylated saponin, was only detected...
Naturally exposed dogs of an endemic area were vaccinated with the fucose mannose ligand (FML) antigen of Leishmania donovani in formulation with QuilA saponin. The 100% of vaccinees were seropositive to FML and showed intradermal reaction to L. donovani lysate, 2 months after vaccination. The absorbency values and size of intradermal reaction were both significantly higher in vaccinees than in controls...
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