Search results for: R. Stämpfli

Items from 1 to 20 out of 36 results

article

Detecting immunoglobulins in processed sputa

Steven P Cass, Joshua J.C. McGrath, Kiho Son, Katherine Radford, more

Allergy > 76 > 12 > 3798 - 3800

article

Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron‐Dependent Sulfoxide Synthases

Kristina V. Goncharenko, Sebastian Flückiger, Cangsong Liao, David Lim, more

Chemistry – A European Journal > 26 > 6 > 1328 - 1334

Sulfoxide synthases are non‐heme iron enzymes that participate in the biosynthesis of thiohistidines, such as ergothioneine and ovothiol A. The sulfoxide synthase EgtB from Chloracidobacterium thermophilum (CthEgtB) catalyzes oxidative coupling between the side chains of N‐α‐trimethyl histidine (TMH) and cysteine (Cys) in a reaction that entails complete reduction of molecular oxygen, carbon–sulfur...

article

Identification of microRNAs as potential markers of ovarian toxicity

Hayley C. Furlong, Martin R. Stämpfli, Anne M. Gannon, Warren G. Foster

Journal of Applied Toxicology > 38 > 5 > 744 - 752

Exposure to environmental toxicants has been associated with ovarian dysfunction yet sensitive biomarkers of adverse effect are lacking. We previously demonstrated that cigarette smoke exposure induced decreased relative ovarian weight, increased follicle loss and granulosa cell autophagy in mice. We postulate that cigarette smoke exposure will induce changes in the epigenome that can be used to reveal...

article

Targeting Interleukin-17 signalling in cigarette smoke-induced lung disease: Mechanistic concepts and therapeutic opportunities

Abraham B. Roos, Martin R. Stampfli

Pharmacology & Therapeutics > 2017 > 178 > C > 123-131

It is widely accepted that compromised lung function in chronic obstructive pulmonary disease (COPD) is, at least in part, a consequence of persistent airway inflammation caused by particles and noxious gases present in cigarette smoke and indoor air pollution from burning biomass fuel. Currently, the World Health Organization estimates that 80 million people have moderate or severe COPD worldwide...

article

Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, more

Respiratory Research > 2017 > 18 > 1 > 1-4

Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased...

article

Development of the faecal microbiota in foals

M. C. Costa, H. R. Stämpfli, E. Allen‐Vercoe, J. S. Weese

Equine Veterinary Journal > 48 > 6 > 681 - 688

Reasons for performing study The intestinal microbiota is a complex polymicrobial ecosystem that exerts extremely important roles in the development and maintenance of health. Recently, as new sequencing technologies have become more available, there has been a revolution in the understanding of the equine intestinal microbiota. However, studies characterising the pioneer intestinal bacteria colonising...

article

Materials used to simulate physical properties of human skin

A. K. Dąbrowska, G.‐M. Rotaru, S. Derler, F. Spano, more

Skin Research and Technology > 22 > 1 > 3 - 14

BackgroundFor many applications in research, material development and testing, physical skin models are preferable to the use of human skin, because more reliable and reproducible results can be obtained. PurposeThis article gives an overview of materials applied to model physical properties of human skin to encourage multidisciplinary approaches for more realistic testing and improved understanding...

article

Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

Danya Thayaparan, Pamela Shen, Martin R. Stämpfli, Mathieu C. Morissette

Respiratory Research > 2016 > 17 > 1 > 1-8

Background Chronic cigarette smoke exposure is known to activate the adaptive immune system; however, the functional role of these processes is currently unknown. Given the role of oxidized lipids in driving innate inflammatory responses to cigarette smoke, we investigated whether an adaptive immune response against damaged lipids was induced following chronic cigarette smoke exposure. Methods and...

article

Small airway epithelial-C/EBPβ is increased in patients with advanced COPD

Michiko Mori, Leif Bjermer, Jonas S. Erjefält, Martin R. Stampfli, more

Respiratory Research > 2015 > 16 > 1 > 1-3

The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs...

article

Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs

Marcio C Costa, Henry R Stämpfli, Luis G Arroyo, Emma Allen-Vercoe, more

BMC Veterinary Research > 2015 > 11 > 1 > 1-12

Background The intestinal tract is a rich and complex environment and its microbiota has been shown to have an important role in health and disease in the host. Several factors can cause disruption of the normal intestinal microbiota, including antimicrobial therapy, which is an important cause of diarrhea in horses. This study aimed to characterize changes in the fecal bacterial populations of healthy...

article

Clinical utility of serum biochemical variables for predicting acid–base balance in critically ill horses

Henry R. Stämpfli, Angelika Schoster, Peter D. Constable

Veterinary Clinical Pathology > 43 > 4 > 547 - 556

BackgroundProfiles from serum biochemical analyzers include the concentration of strong electrolytes (including l‐lactate), total carbon dioxide (tCO₂), and total protein. These variables are associated with changes in acid–base balance. Application of physicochemical principles may allow predicting acid–base balance from serum biochemistry without measuring whole blood pH and pCO₂. ObjectivesThe...

article

Impact of inflammation, emphysema, and smoking cessation on V/Q in mouse models of lung obstruction

Brian N Jobse, Cory Ajr McCurry, Mathieu C Morissette, Rod G Rhem, more

Respiratory Research > 2014 > 15 > 1 > 1-9

Background Chronic obstructive pulmonary disease (COPD) is known to greatly affect ventilation (V) and perfusion (Q) of the lung through pathologies such as inflammation and emphysema. However, there is little direct evidence regarding how these pathologies contribute to the V/Q mismatch observed in COPD and models thereof. Also, little is known regarding how smoking cessation affects V/Q relationships...

article

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Mathieu C Morissette, Brian N Jobse, Danya Thayaparan, Jake K Nikota, more

Respiratory Research > 2014 > 15 > 1 > 1-10

Formation of pulmonary tertiary immune structures is a characteristic feature of advanced COPD. In the current study, we investigated the mechanisms of tertiary lymphoid tissue (TLT) formation in the lungs of cigarette smoke-exposed mice. We found that cigarette smoke exposure led to TLT formation that persisted following smoking cessation. TLTs consisted predominantly of IgM positive B cells, while...

article

Friction between human skin and medical textiles for decubitus prevention

G.-M. Rotaru, D. Pille, F.K. Lehmeier, R. Stämpfli, more

Tribology International > 2013 > 65 > Complete > 91-96

Decubitus ulcers or pressure ulcers are a major health problem. This study investigated the possibility of using low-friction bed sheets with optimized moisture transport properties for the prevention of decubitus ulcers. The tribological behavior of a newly developed prototype in contact with human skin was investigated in vivo. For comparison conventional hospital bed sheets were also investigated...

article

Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models

Jake K. Nikota, Martin R. Stämpfli

Pulmonary Pharmacology & Therapeutics > 2012 > 25 > 4 > 257-262

While the devastating impact of tobacco on human health is well established, and efforts to reduce its prevalence are ongoing, over 1 billion people continue to smoke. Emerging evidence suggests that cigarette smoking distorts lung immune homeostasis, compromising respiratory host defense. Consequently, viral and bacterial agents are dealt with inefficiently and are associated with exaggerated immune...

article

Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice

Fernando M Botelho, Jake K Nikota, Carla Mt Bauer, Mathieu C Morissette, more

Respiratory Research > 2012 > 13 > 1 > 1-10

Background Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. Methods Mice were exposed to cigarette smoke using a whole body smoke exposure system. IL-1R1-, TLR4-, and IL-1α-deficient...

article

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation

Jake K Nikota, Fernando M Botelho, Carla Mt Bauer, Manel Jordana, more

Respiratory Research > 2011 > 12 > 1 > 1-12

Background While the presence of the chitinase-like molecule YKL40 has been reported in COPD and asthma, its relevance to inflammatory processes elicited by cigarette smoke and common environmental allergens, such as house dust mite (HDM), is not well understood. The objective of the current study was to assess expression and function of BRP-39, the murine equivalent of YKL40 in a murine model of...

article

Lung epithelial C/EBPβ is necessary for the integrity of inflammatory responses to cigarette smoke

Abraham B. Roos, Lukas Didon, Jenny L. Barton, Gordon J. Gaschler, more

The Clinical Respiratory Journal > 5 > s1 > 5 - 5

article

Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs

M. Firoz Mian, Elizabeth A. Pek, Karen L. Mossman, Martin R. Stämpfli, more

Molecular Immunology > 2009 > 46 > 15 > 3108-3116

Both NK cells and IL-15 play crucial roles in innate immunity against viral infections and cancer. Cigarette smoke is known to increase susceptibility to infections and certain cancers. Interleukin (IL)-15 plays an important role in immune responses by regulating proliferation, survival and functions of NK cells. Here, we examined the impact of cigarette smoke on IL-15 production and IL-15 mediated...

article

Enhanced acoustic damping in flexible polyurethane foams filled with carbon nanotubes

R. Verdejo, R. Stämpfli, M. Alvarez-Lainez, S. Mourad, more

Composites Science and Technology > 2009 > 69 > 10 > 1564-1569

Flexible polyurethane (PU) foams, with loading fractions of up to 0.2 wt% carbon nanotubes (CNTs), were made by free-rising foaming using water as blowing agent. Electron microscopy revealed an open cellular structure and a homogeneous dispersion of CNTs, although the incorporation of nanofiller affected the foaming process and thus the final foam density and cellular structure. The compressive response...

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INFONA - science communication portal

Search results for: R. Stämpfli

Detecting immunoglobulins in processed sputa

Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron‐Dependent Sulfoxide Synthases

Identification of microRNAs as potential markers of ovarian toxicity

Targeting Interleukin-17 signalling in cigarette smoke-induced lung disease: Mechanistic concepts and therapeutic opportunities

Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Development of the faecal microbiota in foals

Materials used to simulate physical properties of human skin

Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

Small airway epithelial-C/EBPβ is increased in patients with advanced COPD

Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs

Clinical utility of serum biochemical variables for predicting acid–base balance in critically ill horses

Impact of inflammation, emphysema, and smoking cessation on V/Q in mouse models of lung obstruction

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Friction between human skin and medical textiles for decubitus prevention

Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models

Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation

Lung epithelial C/EBPβ is necessary for the integrity of inflammatory responses to cigarette smoke

Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs

Enhanced acoustic damping in flexible polyurethane foams filled with carbon nanotubes

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