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The validity of PTCA as a clinical model of preconditioning is debated as there is potential for acutely recruitable collaterals (ARC) to open. This study assessed the minimal ischaemic interval to induce a protective response at PTCA whilst evaluating ARC flow. 18 patients (14 male) aged 5516 with absent spontaneous collaterals undergoing PTCA to LAD lesions were assigned to one of three protocols:...
Objective Changes of energy metabolism in the failing human heart could further exacerbate functional deterioration. Our aim is to evaluate the nature of the abnormalities of myocardial energy metabolism in the human heart at end stage heart failure due to hypertrophic or dilated cardiomyopathy.Methods Left ventricle cardiac specimens from patients undergoing heart transplantation with dilated cardiomyopathy...
Objective Nucleoside transport inhibitors (NTI) increase adenosine concentration, however, the metabolic consequences of prolonged exposure to NTI and its combined effect with nucleotide precursors has not been established in myocytes. This study investigated the effects of two NTI, 10 μM dipyridamole (DIPY) and 1 μM nitrobenzylthioinosine (NBTI) alone or combined with 100 μM adenine/2.5 mM ribose...
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