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Adenosine deaminases acting on RNA (ADARs) are proteins that catalyse widespread A‐to‐I editing within RNA sequences. We recently reported that ADAR2 edits and stabilizes nuclear‐retained Cat2 transcribed nuclear RNA (Ctn RNA). Here, we report that ADAR1 coordinates with ADAR2 to regulate editing and stability of Ctn RNA. We observe an RNA‐dependent interaction between ADAR1 and ADAR2. Furthermore,...
Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-restricted deletion of Adar1, we demonstrate that ADAR1 is dispensable for myelopoiesis but is essential...
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