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Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are candidate cells‐of‐origin for DMG, yet there is no genetically engineered mouse model of DMG initiated in OPCs. Here, we used the RCAS/Tv‐a avian retroviral system to generate DMG in Olig2‐expressing...
• The endoplasmic reticulum protein, stromal interaction molecule 1 (STIM1), activates Orai1 channels by directly interacting with each Orai1 subunit at the C‐ and N‐termini. Current models about the roles of these sites are rooted in notions of modularity, with the C‐terminal site thought to mediate STIM1 binding and the N‐terminal site thought to regulate channel gating.
• Here we report that the...
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