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Specifications are the regulatory and legal standards that a product must meet to be suitable for use in humans. Specifications evolve in parallel with drug development and are refined prior to marketing authorization and, in some cases, after marketing. Recent changes in regulatory procedures for biotechnology-derived protein products have placed much emphasis on the use of characterization and final...
Displaceable binding of [ 3 H]forskolin to human platelet membranes can be detected in the presence of magnesium. There is an increase in the number of [ 3 H]forskolin binding sites when membranes are incubated with GppNHp or NaF in the presence of magnesium. Prostaglandin E 1 , which stimulates human platelet adenylate cyclase, does not affect the binding of [ 3 H]forskolin...
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