Search results for: Spencer A. Brown

Items from 1 to 18 out of 18 results

article

The endothelial cell secretome as a novel treatment to prime adipose-derived stem cells for improved wound healing in diabetes

Marc W. Fromer, Shaohua Chang, Ashleigh L.R. Hagaman, Kiavash R. Koko, more

Journal of Vascular Surgery > 2018 > 68 > 1 > 234-244

Chronic wounds are a common surgical problem exacerbated by diabetes and ischemia. Although adipose-derived stem cells (ASCs) have shown promise as a wound healing therapy, their function and proliferation are hindered in diabetes. This study examines the ability of the human umbilical vein endothelial cell (HUVEC) secretome to reverse the deleterious effects of high glucose concentrations on ASCs...

article

Fibroblast growth factor and vascular endothelial growth factor play a critical role in endotheliogenesis from human adipose-derived stem cells

Sophia Khan, Miguel A. Villalobos, Rachel L. Choron, Shaohua Chang, more

Journal of Vascular Surgery > 2017 > 65 > 5 > 1483-1492

Adipose-derived stem cells (ASCs) are a potential adult mesenchymal stem cell source for restoring endothelial function in patients with critical limb ischemia. Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF) play a major role in angiogenesis and wound healing. This study evaluated the effects of FGF and VEGF on the proliferation, migration, and potential endothelial...

article

In vitro effects of tamoxifen on adipose‐derived stem cells

Steven Pike, Ping Zhang, Zhengyu Wei, Nan Wu, more

Wound Repair and Regeneration > 23 > 5 > 728 - 736

In breast reconstructive procedures, adipose‐derived stem cells (ASCs) that are present in clinical fat grafting isolates are considered to play the main role in improving wound healing. In patients following chemotherapy for breast cancer, poor soft tissue wound healing is a major problem. However, it is unclear if tamoxifen (TAM) as the most widely used hormonal therapeutic agent for breast cancer...

article

Mechanical Performance of Surgical Knots in a Vaginal Surgery Model

Sunil Balgobin, Cherine A. Hamid, Spencer A. Brown, Clifford Y. Wai

Journal of Surgical Education > 2013 > 70 > 3 > 340-344

To evaluate the integrity of 3 different types of sliding knots in a vaginal surgery model.Nonidentical sliding (NS), loop-to-strand sliding (LTS), and parallel sliding (PS) knots with 4 throws each were tied on a vaginal surgery model with 0 polyglactin-910 and tested until failure. The main outcomes studied were the maximum load reached at failure and the proportion of each type of sliding knot...

article

Surgical Knot Integrity: Effect of Suture Type and Caliber, and Level of Residency Training

Meadow M. Good, Levi B. Good, Donald D. McIntire, Spencer A. Brown, more

Journal of Surgical Education > 2013 > 70 > 1 > 156-160

To evaluate if suture type and caliber or level of residency training affects strength and mode of failure of surgical knots. All residents in an obstetrics and gynecology training program were invited to tie knots on a bench model using 2 calibers (0 and 3-0) of 2 types of surgical suture (polyglactin 910 and polydioxanone). The failure load, mode of failure, and loop lengths of the knots were...

article

Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?

Georgette Oni, Spencer A. Brown, Jeffrey M. Kenkel

Lasers in Surgery and Medicine > 44 > 2 > 168 - 174

Background and ObjectiveIt has been shown in vitro that pretreatment of skin with fractional lasers enhances transdermal delivery of drugs. The aim of this study is to demonstrate in vivo firstly that laser enhances transdermal drug absorption and secondly that this can be manipulated by altering laser settings. Study Design/Materials and MethodsFour pigs were used in the IACUC approved animal study...

article

The use of non‐invasive instruments in characterizing human facial and abdominal skin

Steven H. Bailey, Georgette Oni, Spencer A. Brown, Natalie Kashefi, more

Lasers in Surgery and Medicine > 44 > 2 > 131 - 142

Background and ObjectiveThe skin is highly variable. This variation, although helpful for function, causes inconsistencies when assessed using subjective scales. The purpose of this study is to measure differences in skin on the face and abdomen using non‐invasive, objective devices as a method to eliminate subjective error and help reduce intra‐ and inter‐observer variability in clinical analysis...

article

An in vivo histopathological comparison of single and double pulsed modes of a fractionated CO₂ laser

Georgette Oni, Daniel Robbins, Steven Bailey, Spencer A. Brown, more

Lasers in Surgery and Medicine > 44 > 1 > 4 - 10

IntroductionStudies examining the histopathological changes that occur in human skin following fractional laser treatment have been performed mainly in animals or abdominal tissue prior to abdominoplasty. This study looks at the effect of double pulse fractional CO₂ laser compared to single pulse treatments to assess differences in tissue injury in the face and abdomen. MethodsTwelve healthy subjects...

article

An intra‐individual quantitative assessment of acute laser injury patterns in facial versus abdominal skin

Steven H. Bailey, Spencer A. Brown, Yeonsoon Kim, Georgette Oni, more

Lasers in Surgery and Medicine > 43 > 2 > 99 - 107

IntroductionClinical laser settings have traditionally been calibrated on abdominal skin to predict and anticipate patterns of injuries in facial skin. This experimental approach has limitations as facial skin and abdominal skin have differences that may influence the depth of laser injury. ObjectiveThe primary objective of this study is to analyze the acute pattern of laser injury in abdominal skin...

article

Adipose derived stem cells: efficiency, toxicity, stability of BrdU labeling and effects on self-renewal and adipose differentiation

Charlotte Lequeux, Georgette Oni, Ali Mojallal, Odile Damour, more

Molecular and Cellular Biochemistry > 2011 > 351 > 1-2 > 65-75

5-bromo-2-deoxyurudine (BrdU) can be used as a methodological tool for in vivo investigations following in vitro prelabeling of isolated stem cells for subsequent cell tracking within the recipient host. The objective of this study was to determine how useful BrdU may be as a labeling modality for adipose derived stem cells (ASC) by examining BrdU toxicity, BrdU intracellular stability, and potential...

article

Efficacy of Lidocaine for Pain Control in Subcutaneous Infiltration During Liposuction

Daniel A. Hatef, Spencer A. Brown, Avron H. Lipschitz, Jeffrey M. Kenkel

Aesthetic Surgery Journal > 2009 > 29 > 2 > 122-128

Liposuction remains the most commonly performed aesthetic surgical procedure in the United States. Preoperative infiltration of the subcutaneous tissues with a wetting solution has become standard. These solutions typically contain some amount of lidocaine for pain control. High doses of lidocaine have been demonstrated to be safe, but large amounts of this cardioactive agent during elective cosmetic...

article

Biomechanical properties of the vaginal wall: effect of pregnancy, elastic fiber deficiency, and pelvic organ prolapse

David D. Rahn, Matthew D. Ruff, Spencer A. Brown, Harry F. Tibbals, more

American Journal of Obstetrics and Gynecology > 2008 > 198 > 5 > 590.e1-590.e6

The purpose of this study was to identify pregnancy-induced changes in biomechanical properties of the vaginal wall and to compare these with fibulin-5 knockout mice (Fbln5 ^−/− ) with and without prolapse.Mid-vaginal segments of nonpregnant and late-pregnant wild-type mice, Fbln5 ^−/− with prolapse mice and Fbln5 ^−/− mice without prolapse were studied. Tissue length at failure,...

article

The effect of blood pressure on hematoma formation with perioperative Lovenox in excisional body contouring surgery

Jordan P. Farkas, Jeffrey M. Kenkel, Daniel A. Hatef, Gabrielle Davis, more

Aesthetic Surgery Journal > 2007 > 27 > 6 > 589-593

Prophylactic use of low molecular weight heparin (LMWH) has been shown to be efficacious in decreasing thromboembolism. LMWHs are associated with increased rates of bleeding. We reviewed perioperative blood pressure dynamics for patients who experienced hematomas while undergoing body contouring procedures while receiving enoxaparin (Lovenox), compared with similar patients who did not have development...

article

The science of mesotherapy: Chemical anarchy

Spencer A. Brown

Aesthetic Surgery Journal > 2006 > 26 > 1 > 95-98

The author stresses that to date, the effects of mesotherapy have not been scientifically evaluated. Currently, there is no standardization of dosage and no protocol or treatment algorithm to enable prediction of how much tissue or fat will be “dissolved” with a specific solution in a defined quantity, and injected at a specified subcutaneous tissue depth.

article

Shock Wave Lithotripsy Causes Ipsilateral Renal Injury Remote From the Focal Point: The Role of Regional Vasoconstriction

FERNANDO C. DELVECCHIO, BRIAN K. AUGE, RAVI MUNVER, SPENCER A. BROWN, more

The Journal of Urology > 2003 > 169 > 4 > 1526-1529

Shock wave lithotripsy induced renal damage can occur as a result of multiple mechanisms, including small vessel injury and free radical production. Previous studies have demonstrated that shock wave lithotripsy exerts a regional change in renal hemodynamics, resulting in a global reduction in the glomerular filtration rate and renal plasma blood flow. We determined if biochemical evidence of cellular...

article

IN VIVO ASSESSMENT OF FREE RADICAL ACTIVITY DURING SHOCK WAVE LITHOTRIPSY USING A MICRODIALYSIS SYSTEM: THE RENOPROTECTIVE ACTION OF ALLOPURINOL

RAVI MUNVER, FERNANDO C. DELVECCHIO, RAMSAY L. KUO, SPENCER A. BROWN, more

The Journal of Urology > 2002 > 167 > 1 > 327-334

Shock wave lithotripsy is believed to cause renal damage directly through cellular injury from high energy shock waves and indirectly through vascular injury and resultant ischemia, which gives rise to oxygen free radical compounds. The transient and volatile nature of free radicals and derived products makes their detection difficult. Moreover, certain medications may provide a protective effect...

article

Microdialysis assessment of shock wave lithotripsy-induced renal injury

Spencer A. Brown, Ravi Munver, Fernando C. Delvecchio, Ramsay L. Kuo, more

Urology > 2000 > 56 > 3 > 364-368

Objectives. Shock wave lithotripsy (SWL) is the primary treatment modality for managing the majority of symptomatic renal calculi. However, the fundamental mechanisms for stone fragmentation and the resultant morphologic changes that occur are not fully understood. Furthermore, a thorough understanding of the complex biologic pathways involved in SWL-induced renal injury does not exist at present...

article

Effect of thyroxine on acid lipase activity of adult rat liver

Paul M. Coates, Spencer A. Brown, Herbert Lau, L. Krulich, more

FEBS Letters > 1978 > 86 > 1 > 45-48

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Spencer A. Brown

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options