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TNF therapy is effective for all aspects of psoriatic disease, but these drugs are costly and the long-term effects are unknown. Further, methotrexate causes concern with long-term adverse events. The purpose of this pilot study was to test the feasibility of drug withdrawal from patients with psoriatic arthritis, in stable low disease state. We examined the availability of patients, their willingness...
Tight control of inflammation with a prespecified target optimises outcome and is now considered standard of care in rheumatoid arthritis but has never been evaluated in psoriatic arthritis. We aimed to assess the effect of tight control on early psoriatic arthritis using a treat-to-target approach. In a UK multicentre, open-label, parallel group, randomised, controlled trial in eight rheumatology...
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