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Comparative genomic hybridization serves as a screening test for regions of copy number changes in tumor genomes. We have applied the technique to map DNA gains and losses in 5 cell lines derived from glioblastoma multiforme, the most common primary neoplasm of the central nervous system. The most frequent losses occurred on chromosomes 10 and 13. The most common gains were observed on chromosomes...
TheTFDPgenes encode a family of transcription factors that can form heterodimers withE2Ffamily proteinsin vivo.The E2F–TFDP transcription factors are major regulators of genes that are required for the progression of S-phase, such as DHFR and DNA polymerase α, and they play a critical role in cell cycle regulation and differentiation. The retinoblastoma tumor suppressor protein has been shown to induce...
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