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Hypoxic inhibition of background K + channels is crucial to O 2 sensing by chemoreceptor tissues, but direct demonstration of O 2 sensitivity by any member of this K + channel family is lacking. HEK293 cells were transfected with a pcDNA3.1-hTASK1 construct; expression of hTASK1 was verified using RT-PCR and immunocytochemistry. Whole-cell K + currents of cells...