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We have used gene competition to distinguish between possible mechanisms of transcriptional activation of the genes of the human β-globin locus. The insertion of a second β-globin gene at different points in the locus shows that the more proximal β gene competes more effectively for activation by the locus control region (LCR). Reducing the relative distance between the genes and the LCR reduces the...
Locus control regions (LCRs) are responsible for initiating and maintaining a stable tissue-specific open chromatin structure of a locus. In transgenic mice, LCRs confer high level expression on linked genes independent of position in the mouse genome. Here we show that an incomplete LCR loses this property when integrated into heterochromatic regions. Two disruption mechanisms were observed. One...
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