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Background: Phospholipase D (PLD) hydrolyzes phospholipids to generate phosphatidic acid (PA) and a free headgroup. PLDs occur as both intracellular and secreted forms; the latter can act as potent virulence factors. Exogenous PLD has growth-factor-like properties, in that it induces proto-oncogene transcription, mitogenesis and cytoskeletal changes in target cells. The underlying mechanism is unknown,...
The application of endogenous-like particles for the targeting of drugs to specific sites in the body is advantageous because endogenous transport vehicles do not trigger immunological reactions, are completely biodegradable, and escape recognition by the reticuloendothelial system (stealth behaviour). In the present study a lipid emulsion is prepared that mimics lipoprotein particles (so-called...
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