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The relationship between the rate of glutathione disulfide (GSSG) export and the energy state was studied in isolated perfused rat heart. The intracellular GSSG level was maintained at saturation for transport (7.5 nmol GSSG . min -1 . g heart -1 ) by continuous perfusion with 20 μM t-butyl hydroperoxide. GSSG release was substantially restricted upon the addition of inhibitors...