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A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.
We investigated the ability of sulfated cholecystokinin (CCK-8) and cholecystokinin (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (IV), intracerebroventricular (ICV), or intraperitoneal (IP) administration. Significant TAC was induced by IP administration of CCK-8 at 0.1 but not at 0.025, 0.5, or 1.0 μmol/kg; the TAC was...
Administration of a relatively large IP dose of sulfated cholecystokinin (26-33) (CCK-8; 1.0 μmol/kg) consistently induced moderate taste aversion conditioning (TAC) using a 20-min, one-bottle test in Long-Evans rats. Because CCK-8 has affinity for both CCK A and CCK B receptor subtypes, we wanted to determine the subtype involved in CCK-8-induced TAC. Pretreatment with the selective...
Using a one-bottle taste aversion conditioning paradigm, sulfated cholecystokinin(26-33) (CCK-8) has again been shown to induce taste aversion conditioning in rats. Even though the effective doses of CCK-8 are relatively high, they do not induce as strong an aversion as has been demonstrated with LiCl. This pharmacodynamic profile of CCK-8 (i.e., relatively moderate, but not strong, taste aversion...
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