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Alzheimer’s disease is associated with amyloid-β plaques eliciting neuronal oxidative stress. Many naturally occurring compounds have antioxidant properties, but it is unclear if this alone protects against amyloid-β exposure. This study investigated the protective effects of selected bioactive compounds against amyloid-β and pro-oxidant-evoked neurotoxicity in PC12 cells. Neither resveratrol, (−)-epigallocatechin-3-gallate,...
Superoxide anion (O 2.- ) production from human neutrophils stimulated by N-formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP, 1 μM) was inhibited by preparations of the inhibitor of cAMP-dependent protein kinase, Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS, 100 μM). This effect of Rp-cAMPS was reversed by xanthine amine congener (0.1 μM), an adenosine receptor antagonist,...
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