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Background: On the basis of experiments suggesting that Notch and Delta have a role in axonal development in Drosophila neurons, we studied the ability of components of the Notch signaling pathway to modulate neurite formation in mammalian neuroblastoma cells in vitro.Results: We observed that N2a neuroblastoma cells expressing an activated form of Notch, Notch1 IC , produced shorter neurites...
Studies in invertebrates have indicated a functional requirement for presenilin (PS) genes in the Notch pathway [1–5]. One model of Notch signal transduction suggests that proteolysis releases an activated Notch fragment that migrates to the nucleus and regulates gene transcription in concert with CBF1/Su(H)/lag1 (CSL) proteins [6–9]. Recent studies suggest that PS genes control the proteolysis and...