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In rats, chronic ethanol consumption results in moderate hypoglycemia with no great changes in the diurnal patterns of blood glucose and hepatic glucose. Marked alterations of the diurnal rhythm of liver glycogen were observed in ethanol-fed animals, the phase of the rhythm being shifted and the daily mean and minimum levels being lowered. After withdrawal of ethanol consumption, blood glucose remained...
Studies were undertaken to determine whether the distribution of glycolytic intermediates between the blood and liver in rats would be changed upon ethanol consumption and after its withdrawal. More drastic impairment of energy metabolism appeared to occur after ethanol withdrawal than upon chronic ethanol ingestion. The major metabolic manifestations of withdrawal were severe hypoglycemia, hyperlactatemia...
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