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Gene expression of human immunodeficiency virus (HIV) depends on a host cellular transcription factors including nuclear factor-κB (NF-κB). The involvement of reactive oxygen intermediates (ROI) has been implicated as intracellular messengers in the inducible activation of NF-κB. In this study, we compared the efficacy of two antioxidants, α-lipoic acid (LA) and N-acetylcysteine (NAC), which are...
Nuclear factor κB (NF-κB) is a transcription factor that is critical for the inducible expression of multiple cellular and viral genes. DNA binding activity is essential for its function. Here, we report that gold compounds, especially aurothioglucose (AuTG), have a strong inhibitory effect on NF-κB-DNA binding. Our finding also reveals that Zn 2+ is a necessary component of NF-κB for...
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