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Androgen excess and deficiency affect skeletal maturation and bone cell function. Understanding the molecular basis for these androgen effects could improve therapy/prevention of short stature and osteoporosis. Androgens act through binding to androgen receptors (ARs), which modulate gene transcription via interactions with DNA response elements on target genes. Because osteoblasts contain ARs at...
Hepatocyte growth factor (HGF) has been implicated as a paracrine regulator of organogenesis and repair in many tissues. Here we have studied the expression and actions of HGF in intact rachitic rat growth plate and derived cultures of proliferative zone chondrocytes. In vivo and in vitro chondrocytes express HGF mRNA; 1,25(OH) 2 has a three-fold maximal stimulatory effect, which can be...
Calcitonin gene-related peptide (CGRP) was examined for its effects on intracellular free Ca 2+ concentration ([Ca 2+ ] i ) in UMR 106 osteoblast-like cells. Cells loaded with the Ca 2+ dye FURA-2 dose-dependently responded to CGRP (1-100 nM) with transient two-fold increases in [Ca 2+ ] i . An intracellular source for this Ca ...
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