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Prostaglandin E 2 (PGE 2 ) is bone-anabolic, i.e. stimulates bone formation and increases bone mass. In this study, we explored possible intracellular mechanisms of its increase of osteogenic cells in rat bone marrow. Adherent rat bone marrow cells were counted after 12–48h or cultured for 21 days and mineralized nodules were counted. Also, apoptosis of marrow cells was measured after...
Prostaglandins E (especially PGE 2 ) stimulate bone formation and increase bone mass in several species including man. The mechanism for this effect, the target cells, and the receptors involved are not known. Specific cell-surface receptors for PGE 2 (EP 1-4 ) have been cloned and characterized. EP 4 was reported to be the major receptor in embryonic and...
Growth plate width and cartilage organization are altered during skeletal unloading in growing rats. Immunohistochemical studies have identified TGF-β in calcified cartilage, and TGF-β is known to induce mitogenic effects on chondrocytes in vitro. On the other hand, IGF-1 was shown to be expressed in the proximal tibial growth plate and to mediate GH-induced longitudinal bone growth in rats. We...
Growth plate histomorphometry of rats after spaceflight or on-Earth unloading showed marked alterations in cell organization (D. Montufar-Solis et al., J. Appl. Physiol., 73, 19S, 1992; D. Montufar-Solis and J. Duke, Am. Soc. Gravitational Space Biol., 1, 34, 1988). The regulation of longitudinal bone growth (LBG) is complex, as it includes among others nutritional and endocrine factors. However,...
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