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We have identified a new gene, that is highly expressed in normal and neoplastic prostate, and is also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS. Database analyses of ESTs indicated prostate specificity but experimental results showed the expression in other tissues. The full length transcript is 1800 bp with an open reading frame of 526 aa. The amino-terminal...
Background & Aims: Leukotrienes are proinflammatory mediators. Ethanol inhibits the catabolism of both cysteinyl leukotrienes (leukotriene E 4 [LTE 4 ] and N-acetyl-LTE 4 ) and leukotriene B 4 (LTB 4 ) in hepatocytes. We examined the metabolic derangement of leukotriene inactivation by ethanol in humans in vivo. Methods: LTE 4 , N-acetyl-LTE ...
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