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Selective serotonin reuptake inhibitor (SSRI) augmentation with the 5-HT 1A antagonist pindolol has met with mixed results. Recent studies using positron emission tomography (PET) suggest that pindolol doses used in these studies were too low to effect 5-HT 1A autoreceptor blockade. To test the hypothesis that a single higher dose of pindolol would effectively augment antidepressant...