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Recent transcription mapping efforts within chromosome 17q21 have led to the identification of a human homolog of theDrosophilageneEnhancer of zeste, E(z). A member of the Polycomb group (Pc-G) of proteins,Drosophila E(z) acts as a negative regulator of the segment identity genes of the Antennapedia and Bithorax complexes. Here we report the full-length protein coding sequence of humanEZH1(Enhancer...
Direct selection of genes within the interval of chromosome 17q21 containing BRCA1 was performed. YAC and cosmid contigs spanning the BRCA1 region were used to select cDNA clones from pools of cDNAs derived from human placenta, HeLa cells, activated T cells, and fetal head. A minimum set of 48 fragments of nonoverlapping cDNAs that unequivocally mapped within a 1-Mb region was identified, although...