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Several previous studies reported the association of the soluble form of amyloid β (sAβ) protein, a major constituent of amyloid deposits in Alzheimer's disease (AD), with normal blood, cerebrospinal fluid (CSF) and central nervous system high density lipoproteins (HDLs). The present report aimed to elucidate the pattern of sAβ and apolipoprotein (apo) distribution in AD CSF-HDL subfractions. We studied...
Herein we describe the inhibitory effect of the synthetic peptide Aβ1-40, homologous to the major high-density lipoprotein-associated species of Alzheimer's amyloid β protein (Aβ), on lipid biosynthesis in human hepatic HepG2 cells. This culture synthesizes various lipids from [ 14 C]acetate as a precursor. Treatment of cells with different concentrations of Aβ1-40 decreased the syntheses...
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