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The great majority of breast cancers are in their early stage hormone-dependent and it is well accepted that estradiol (E 2 ) plays an important role in the genesis and evolution of this tumor. Human breast cancer tissues contain all the enzymes: estrone sulfatase, 17β-hydroxysteroid dehydrogenase, aromatase involved in the last steps of E 2 bioformation. Sulfotransferases which convert...