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Pamidronate (Pam.) is the most potent of the available bisphosphonates and we evaluated the biochemical dose-response effects of a first infusion of Pam.in postmenopausal women (median 13, range 1-47 yrs after menopause) with low bone mass (T score <-1.0 at the lumbar spine or the femoral neck level). We measured in 2-hr morning fasting specimens urinary Ca (NI<0.16 mg Ca/mg Creat), hydroxyproline...
Abstract. Circulating interleukin-6 (IL-6) concentrations correlate with disease activity in severe inflammatory conditions, in sepsis and in some hematological malignancies. On the other hand, IL-6 is a potent stimulator of osteoclastogenesis and has been implicated as a contributory factor in the genesis of osteopenic conditions. We measured circulating IL-6 levels by a sensitive (detection limit...
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