Joseph A. Spadaro

chapter

Bone Loss in the Forearm after Disuse: Response Variability and the Role of Systemic Factors

Joseph A. Spadaro

2013 39th Annual Northeast Bioengineering Conference > 195 - 196

2013 39th Annual Northeast Bioengineering Conference (NEBEC)

Bone density loss in the forearm following cast immobilization was examined with time for 6 months after re-ambulation. Although there was a substantial bone loss, here was a substantial variability as well. This analysis examined the various levels of response as well as some systemic factors that may offer some insights.

article

Electromagnetic effects on forearm disuse osteopenia: A randomized, double‐blind, sham‐controlled study

Joseph A. Spadaro, Walter H. Short, Paul R. Sheehe, Rebecca M. Hickman, more

Bioelectromagnetics > 32 > 4 > 273 - 282

A randomized, double‐blind, sham‐controlled, feasibility and dosing study was undertaken to determine if a common pulsing electromagnetic field (PEMF) treatment could moderate the substantial osteopenia that occurs after forearm disuse. Ninety‐nine subjects were randomized into four groups after a distal radius fracture, or carpal surgery requiring immobilization in a cast. Active or identical sham...

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Microarray Cluster Analysis of Irradiated Growth Plate Zones Following Laser Microdissection

Timothy A. Damron, Mingliang Zhang, Meredith R. Pritchard, Frank A. Middleton, more

International Journal of Radiation Oncology, Biology, Physics > 2009 > 74 > 3 > 949-956

Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective radiorecovery modulation.Three groups of six 5-week male Sprague-Dawley rats underwent fractionated irradiation to the right tibiae over 5 days, totaling 17.5 Gy, and then were killed at 7, 11, and 16 days after the first radiotherapy fraction. The growth...

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Distal Radius Strength: A Comparison of DXA-Derived vs pQCT-Measured Parameters in Adolescent Females

Jodi N. Dowthwaite, Rebecca M. Hickman, Jill A. Kanaley, Robert J. Ploutz-Snyder, more

Journal of Clinical Densitometry > 2009 > 12 > 1 > 42-53

Although quantitative computed tomography (QCT) is considered the gold standard for in vivo densitometry, dual-energy X-ray absorptiometry (DXA) scans assess larger bone regions and are more appropriate for pediatric longitudinal studies. Unfortunately, DXA does not yield specific bone architectural output. To address this issue in healthy, postmenarcheal girls, Sievänen's distal radius formulae [1996]...

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Bone Geometry, Density, and Strength Indices of the Distal Radius Reflect Loading via Childhood Gymnastic Activity

Jodi N. Dowthwaite, Portia P.E. Flowers, Joseph A. Spadaro, Tamara A. Scerpella

Journal of Clinical Densitometry > 2007 > 10 > 1 > 65-75

The distal radius bears unique forces during gymnastic activity. Its relatively simple anatomy, minimal soft tissue envelope, and varied composition make the distal radius ideal for evaluating the effects of loading on bone properties. For 56 premenarcheal gymnasts and nongymnasts, ultradistal and 1/3 distal radius DXA scans measured bone mineral content (BMC), areal bone mineral density, and projected...

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Poster 82 - A preliminary study of dual-energy X-ray absorptiometry positioning protocols for women and girls with mobility disabilities

Margaret A. Turk, Joseph A. Spadaro, Joanne Scandale, Lynne R. Logan, more

Archives of Physical Medicine and Rehabilitation > 2003 > 84 > 9 > E19

Objective: To establish a protocol compensating for contractures in dual-energy x-ray absorptiometry (DXA) hip scans in people with mobility impairments using the DPX-IQ Lunar Pencil Beam Scanner. Design: 3 sets of proximal femur scans taken at 0 ^o , 20 ^o , and 30 ^o of hip flexion, with repositioning between. The bone mineral density (BMD) in hip subregions and the precision...

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Precision and Accuracy of DXA and pQCT for Densitometry of the Rat Femur

Jason A. Horton, Gayle M. Murray, Joseph A. Spadaro, Bryan S. Margulies, more

Journal of Clinical Densitometry > 2003 > 6 > 4 > 381-390

Measurements of bone mineral density and bone mineral content are key data in the study of osteoporosis and pathologic skeletal disease. Dual-energy X-ray absorptiometry and peripheral quantitative computed tomography are used in human and small animal studies. The purpose of this study was to evaluate the precision, accuracy, and systematic bias of measurement of the rat femur. Comparing machine-measured...

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Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone

Timothy A. Damron, Bryan Margulies, Darius Biskup, Joseph A. Spadaro

International Journal of Radiation Oncology, Biology, Physics > 2001 > 50 > 2 > 479-483

The aim of this study was to determine the independent and combined effects of 100 mg/kg and 200 mg/kg doses of the radioprotectant amifostine and radiotherapy dose fractionation in preserving the integrity of or minimizing damage to the physis during high-dose radiation exposure in an animal model. Thirty-six weanling four-week-old male Sprague-Dawley rats were randomized into six study groups of...

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Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment ¹

Timothy A. Damron, Joseph A. Spadaro, Robert M. Tamurian, Leatha A. Damron

International Journal of Radiation Oncology, Biology, Physics > 2000 > 47 > 4 > 1067-1071

Purpose: The purpose of this study was to determine the relative benefits of sparing longitudinal bone growth by fractionation alone compared to pretreatment with amifostine, a chemical that provides differential radioprotection of normal tissues.Methods and Materials: Twenty-four weanling 4-week-old male Sprague-Dawley rats were randomized into 2 overall treatment groups: fractionation alone (n =...

article

Application of Low-Intensity Ultrasound to Growing Bone in Rats - Biomechanical and gene expression analysis

Joseph A. Spadaro, Stephen A. Albanese

Ultrasound in Medicine & Biology > 1998 > 24 > 4 > 567-573

Low-intensity pulsed ultrasound recently has been shown to accelerate long bone fracture healing, but its effect on bone growth and development is unknown. The longitudinal growth and bone density of the femur and tibia in young rats was measured after application of an ultrasound transducer emitting 1.5-MHz pulsed ultrasound (30 mW/cm ² , SATA) for 20 min/day. After 28 days, no length difference...

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Search results for: Joseph A. Spadaro

Bone Loss in the Forearm after Disuse: Response Variability and the Role of Systemic Factors

Electromagnetic effects on forearm disuse osteopenia: A randomized, double‐blind, sham‐controlled study

Microarray Cluster Analysis of Irradiated Growth Plate Zones Following Laser Microdissection

Distal Radius Strength: A Comparison of DXA-Derived vs pQCT-Measured Parameters in Adolescent Females

Bone Geometry, Density, and Strength Indices of the Distal Radius Reflect Loading via Childhood Gymnastic Activity

Poster 82 - A preliminary study of dual-energy X-ray absorptiometry positioning protocols for women and girls with mobility disabilities

Precision and Accuracy of DXA and pQCT for Densitometry of the Rat Femur

Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone

Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment ¹

Application of Low-Intensity Ultrasound to Growing Bone in Rats - Biomechanical and gene expression analysis

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