Search results for: Buse Cevatemre

Items from 1 to 12 out of 12 results

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The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine

Omer Kacar, Buse Cevatemre, Ibrahim Hatipoglu, Nazli Arda, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 6 > 1770-1777

Palladium complexes are potent and less toxic molecules in comparison to other metal based agents. Here, we characterized two palladium(II) saccharinate complexes with terpyridine for their cell cycle specificity.Cells were arrested at G1, G1/S boundary or mitosis using mimosine, double-Thymidine block, aphidicolin, nocodazole or colcemid, and evaluated based on morphology and flow cytometry. Synchronized...

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Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines

Duygu Tunc, Egemen Dere, Didem Karakas, Buse Cevatemre, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 5 > 1717-1723

Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have strong cytotoxic activity in a similar way as cisplatin. Therefore, metal-based compounds have been synthesized and investigated in order to determine their cytotoxic activities. It...

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Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Seyma Aydinlik, Merve Erkisa, Buse Cevatemre, Mehmet Sarimahmut, more

Biochimica et Biophysica Acta (BBA) - General Subjects > 2017 > 1861 > 2 > 49-57

The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we investigated if the effectiveness of doxorubicin was augmented by the inhibition of autophagy.MDA-MB-231 was used as a model cell line for triple negative breast cancer and 3-methyladenine was...

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Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents

Ceyda Acilan, Buse Cevatemre, Zelal Adiguzel, Didem Karakas, more

Biochimica et Biophysica Acta (BBA) - General Subjects > 2017 > 1861 > 2 > 218-234

To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA, cytotoxicity and mechanism of action.The binding ability of the complexes to Calf-Thymus DNA was evaluated...

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A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer

Nazlihan Aztopal, Didem Karakas, Buse Cevatemre, Ferda Ari, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 1 > 269-276

Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor initiation, maintenance as well as drug resistance. Therefore, targeting the CSCs along with the other cancer cells has been the most important topic during the last decade. In the...

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The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro

Buse Cevatemre, Bruno Botta, Mattia Mori, Simone Berardozzi, more

Chemico-Biological Interactions > 2016 > 260 > C > 248-255

Despite the rapid advances in chemotherapy regimens, the outcome of patients with breast cancer is not satisfactory. One of the reasons of this dissatisfaction is that subsets of cells in tumors which referred as cancer stem cells (CSCs) show and/or gain resistance to therapies. Thus, compounds that target CSCs are urgently needed. Since some are already used in the clinic, natural products have great...

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Validation data supporting the characterization of novel copper complexes as anticancer agents

Ceyda Acilan, Buse Cevatemre, Zelal Adiguzel, Didem Karakas, more

Data in Brief > 2016 > 9 > C > 1160-1174

Three copper(II) complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)pheamine, Cu(Sal-Gly)phepoxy were synthesized and characterized for their anticancer properties and mechanism of action (Acilan et al., in press) [1]. Here, we provide supporting data on colon cancer cell lines complementing our previous findings in cervix cells. This paper also contains a data table for the fold changes and p-values of all...

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Addition of niclosamide to palladium(II) saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer

Didem Karakas, Buse Cevatemre, Nazlihan Aztopal, Ferda Ari, more

Bioorganic & Medicinal Chemistry > 2015 > 23 > 17 > 5580-5586

Wnt signaling is one of the core signaling pathways of cancer stem cells (CSCs). It is re-activated in CSCs and plays essential role in the survival, self-renewal and proliferation of these cells. Therefore, we aimed to evaluate the cytotoxic effects of palladium(II) complex which is formulated as [PdCl(terpy)](sac)2H₂O and its combination with niclosamide which is an inhibitor of Wnt signaling pathway...

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Anti-growth effect of a novel trans-dichloridobis[2-(2-hydroxyethyl)pyridine]platinum (II) complex via induction of apoptosis on breast cancer cell lines

Arzu Yilmaztepe Oral, Buse Cevatemre, Mehmet Sarimahmut, Ceyda Icsel, more

Bioorganic & Medicinal Chemistry > 2015 > 23 > 15 > 4303-4310

Breast cancer still continues to be the leading cause of cancer-related mortality in women worldwide. Although advances have been made in the treatment of this disease during the past decade, new approaches and novel compounds are urgently needed. The aim of this study was to evaluate the cytotoxic activity of trans-[PtCl₂(2-hepy)₂] [2-hepy=2-(2-hydroxyethyl) pyridine] on breast cancer cell lines,...

article

The M30 assay does not detect apoptosis in epithelial-derived cancer cells expressing low levels of cytokeratin 18

Buse Cevatemre, Engin Ulukaya, Mehmet Sarimahmut, Arzu Yilmaztepe Oral, more

Tumor Biology > 2015 > 36 > 9 > 6857-6865

The primary aim of this study was to compare measurement of apoptosis by M30 immunoreactivity (a biomarker for apoptosis) to other apoptosis assays (morphological assessment of nuclei, Annexin-V-FITC staining, DNA fragmentation and PARP cleavage) in vitro. Caspase-cleaved cytokeratin 18 (M30, ccK18) is only produced in epithelial cells and is regarded as a pharmacodynamic biomarker of apoptotic cell...

article

Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo

Ferda Ari, Buse Cevatemre, Elif Ilkay Ikitimur Armutak, Nazlihan Aztopal, more

Bioorganic & Medicinal Chemistry > 2014 > 22 > 17 > 4948-4954

The anti-growth effect of a palladium(II) complex—[PdCl(terpy)](sac)·2H₂O] (sac=saccharinate, and terpy=2,2′:6′,2″-terpyridine)—was tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. Anti-growth effect was assayed by the MTT and ATP viability assays in vitro and then confirmed on Balb/c mice in vivo. The mode of cell death was determined by both histological and biochemical methods...

article

Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro

Engin Ulukaya, Mehmet Sarimahmut, Buse Cevatemre, Ferda Ari, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 4 > 477-482

Successful management of metastatic breast cancer still needs better chemotherapeutic approaches. The combination of fenretinide (4-HPR), a synthetic retinoid inducing apoptosis by ROS generation, and TRAIL, a cell death ligand inducing caspase-dependent apoptosis, might result in more powerful cytotoxic activity. We therefore investigated the cytotoxic activity and resulting cell death mode of this...

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