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CYP1A2 is one of the major hepatic cytochrome P450s that is involved in the metabolism of many drugs, as well as in the activation of chemical carcinogens. To elucidate the transcriptional regulation of the constitutive expression of the mouse Cypla2 gene, the 4.8-kbp 5 ' -flanking region of the gene was analyzed for transcriptional activity using a primary cultured mouse hepatocyte system...