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Synexin (annexin VII) is a cytosolic Ca 2+ -binding protein that promotes membrane fusion and forms voltage-regulated ion channels in artificial and natural membranes. The crystal structure of the C-terminal tetrad repeat from recombinant synexin (annexin VII) of Dictyostelium discoideum was solved to 2.45 Å resolution. The protein crystallized in a dimeric form with two molecules joined face-to-face...