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IL-35 is a novel cytokine of the IL-12 family, existing as a heterodimer of IL-12p35 and EBV-induced gene 3 (Ebi3). IL-35 is produced by natural and inducible regulatory T cells in humans and mice and seems required for optimal suppression. Dexamethasone (Dex) and 1, 25-dihydroxyvitamin D3 (D3) have previously been shown to inhibit IL-12 production in activated dendritic cells (DC) and suppress allogenic...