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This paper reports a droplet microfluidic, sample-to-answer platform for the detection of disease biomarkers and infectious pathogens using crude biosamples. The platform exploited the dual functionality of silica superparamagnetic particles (SSP) for solid phase extraction of DNA and magnetic actuation. This enabled the integration of sample preparation and genetic analysis within discrete droplets,...
We demonstrate a magnetic micromixer designed specifically for rapid active mixing in droplets. The magnetic micromixer is fabricated with composites consisting of magnetite and polydimethylsiloxane (PDMS) using soft lithography techniques. The micromixer spins on the droplet surface and rapidly homogenizes the solution of reagents by actively mixing. The spinning motion also enables the micromixer...
We have developed an all-in-one microfluidic platform that integrates sample preparation and gene analysis on one single device. Our platform takes the advantage of the silica superparamagnetic particle (SSP) based solid phase extraction (SPE) and an all-in-one scheme that performs cell lysis, DNA binding, washing, elution and polymerase chain reaction (PCR) in the same reaction chamber, which greatly...
Magnet actuated droplets on an open surface have shown great potential in biomolecules manipulation. In spite of its simplicity, many factors still need to be considered for successful droplet control. This report presents a microfluidic platform with surface geomorphological features for easy droplet manipulation, facilitating totally integrated sample preparation and gene analysis. Taking the advantage...
We performed on-chip DNA methylation analysis using methylation-specific PCR (MSP) within a high throughput microfluidic droplet array. The device uses of the oil phase as a companion fluid for both sample actuation and compartmentalization. These technical advantages allow for infusion of minute amounts of sample for arrayed MSP analysis, without the added complexities inherent in microfluidic droplet-based...
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