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Background Hemolysis, a rare but potentially serious complication of intravenous immunoglobulin (IVIG) therapy, is associated with the presence of antibodies to blood groups A and B (isoagglutinins) in the IVIG product. An immunoaffinity chromatography (IAC) step in the production process could decrease isoagglutinin levels in IVIG. Objectives Our objectives were to compare isoagglutinin levels...
BACKGROUNDThe passive transfer of antibodies specific to blood groups A and B (also called isoagglutinins) contained in immunoglobulin (Ig)G products for intravenous administration (IVIG) is believed to be largely responsible for rare but sometimes serious IVIG‐related hemolytic events. We present in this work a modification of the manufacturing process of Privigen—a 10% l‐proline–stabilized IVIG...
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