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Emerging evidence supports an inhibitory role for vitamin D in colorectal carcinogenesis; however, the mechanism remains unclear. The adenomatous polyposis coli (APC)/β‐catenin pathway plays a critical role in colorectal carcinogenesis. The purpose of our study is to explore the interactions of vitamin D and APC/β‐catenin pathways in intestinal tumor development. APCmin/+ mice with genetic inactivation...
Introduction: Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene or the CTNNB1 proto-oncogene have been implicated in the initiation of most human colorectal epithelial neoplasms. Glycogen synthase kinase 3β (GSK3B) serves a critical role in regulating their functions by phosphorylating both APC and CTNNB1 to facilitate CTNNB1 degradation. The current studies were performed to...
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